The efficacy of NBT-103 has been validated by several international top research institutes in different animal models. The compound shows effect in disease models and in normal aging and fast aging mice models. Besides improvement in kidney and liver function and improvement of muscle function and total fitness all studies also revealed a decrease of the pro-inflammatory cytokine IL-6. Interesting is the discovery of up-regulation of functional regulatory T-cells (Tregs) by the compound NBT-103 most likely through eliminating cytokines like IL-6. (see mode of action)
In a doxorubicin induced autoimmune model NBT-103 significantly reduces IL-6.
In a fast aging mice model NBT-103 significantly reduces the elevated IL-6
In normal aging mice NBT-103 significantly increases regulatory T-cells ( Tregs)